Tumour lysis syndrome (TLS) is a life-threatening oncological emergency. It is caused by the death, or lysis of large numbers of cancer cells. TLS can occur spontaneously to high turnover of the tumour itself, and/or after anti-cancer drug treatment or radiotherapy.

In this rapid learning you will learn how to:

  • recognise the signs and symptoms of tumour lysis syndrome (TLS)
  • assess the severity
  • initiate the right interventions and escalate care appropriately

Viewing this on mobile? Tell us what you thought. Complete the survey. 


Mini quiz 

Download the eviQ Education app to access exclusive content, including the TLS mini quiz and seven other oncological emergency interactive lessons.

Use the QR code to access to TLS mini quiz, or visit our mini quizzes homepage for more information.

Additional resources

You can use the following resources in the workplace to assist you in caring for patients.

Save a copy of these resources so you can refer back to them in the workplace.
Patient information
  1. Cairo, M. S., B. Coiffier, A. Reiter, et al. 2010. "Recommendations for the evaluation of risk and prophylaxis of tumour lysis syndrome (TLS) in adults and children with malignant diseases: an expert TLS panel consensus." Br J Haematol 149(1):578-586.
  2. Throvardur R. et al. 2017. Emergencies in hematology and oncology. Mayo clin proc. 92(4)):609-641
  3. Hogan DK, Rosenthal LD. Oncologic emergencies in the patient with lymphoma. Seminars in Oncology Nursing. 1998 14(4):312-20.
  4. Jones, G.L., A. Will, G.H. Jackson, et al. 2015. "Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology." Br J Haematol. 169(5):661-71
  5. Howard, S.C., D.P. Jones and C.H. Pui. 2011. "The Tumor Lysis Syndrome." N Engl J Med 364(19): 1844-1854
Create your own user feedback survey