Tumour lysis syndrome (TLS) is a life-threatening oncological emergency. It is caused by the death, or lysis of large numbers of cancer cells. TLS can occur spontaneously to high turnover of the tumour itself, and/or after anti-cancer drug treatment or radiotherapy.

In this rapid learning you will learn how to:

  • recognise the signs and symptoms of tumour lysis syndrome (TLS)
  • assess the severity
  • initiate the right interventions and escalate care appropriately

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Module

Additional resources

You can use the following resources in the workplace to assist you in caring for patients.

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Patient information
References: 
  1. Cairo, M. S., B. Coiffier, A. Reiter, et al. 2010. "Recommendations for the evaluation of risk and prophylaxis of tumour lysis syndrome (TLS) in adults and children with malignant diseases: an expert TLS panel consensus." Br J Haematol 149(1):578-586.
  2. Throvardur R. et al. 2017. Emergencies in hematology and oncology. Mayo clin proc. 92(4)):609-641
  3. Hogan DK, Rosenthal LD. Oncologic emergencies in the patient with lymphoma. Seminars in Oncology Nursing. 1998 14(4):312-20.
  4. Jones, G.L., A. Will, G.H. Jackson, et al. 2015. "Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology." Br J Haematol. 169(5):661-71
  5. Howard, S.C., D.P. Jones and C.H. Pui. 2011. "The Tumor Lysis Syndrome." N Engl J Med 364(19): 1844-1854
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